发明名称 |
N-CARBOXYALKYL-AURISTATINS AND USE THEREOF |
摘要 |
<p>The present application relates to new derivatives, substituted on the N terminus by a carboxyalkyl group, of monomethylauristatin E and monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and to the use of these derivatives for producing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments may be applied as a monotherapy or else in combination with other medicaments or further therapeutic measures.</p> |
申请公布号 |
EP2686336(B1) |
申请公布日期 |
2015.05.06 |
申请号 |
EP20120708034 |
申请日期 |
2012.03.12 |
申请人 |
SEATTLE GENETICS, INC. |
发明人 |
LERCHEN, HANS-GEORG;EL SHEIKH, SHERIF;STELTE-LUDWIG, BEATRIX;SCHUHMACHER, JOACHIM;GNOTH, MARK |
分类号 |
C07K5/02;A61K38/00;A61K47/48;A61P35/00 |
主分类号 |
C07K5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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