Glucagon composition

摘要

There is provided according to the invention an aqueous composition having pH between 4 and 7 comprising (i) glucagon at a concentration of 0.05% w/v or more and (ii) a cationic surfactant selected from benzalkonium salts and benzethonium salts as solubilizing agent in an amount sufficient to dissolve the glucagon in the composition.

主权项

1. An aqueous solution composition having pH between 5 and 7 comprising (i) glucagon having the sequence of SEQ ID NO:1, at a concentration of 0.05 to 0.2% w/v, (ii) benzethonium chloride as a solubilising agent at a concentration of 0.05 to 0.2% w/v, and (iii) an uncharged tonicity modifying agent at a concentration of 50 to 500 mM or mixture of uncharged tonicity modifying agents at a concentration of 50 to 500 mM, wherein the overall concentration of charged species, other than those originating from glucagon and benzethonium chloride, in the composition is at least 2 mM and less than 25 mM.