发明名称 Composition of monoterpenoids having bactericidal properties
摘要 A composition having bactericidal properties comprising; (a) 30%-80% of at least one compound having the formula (I) and (b) 10% to 40% of at least one compound of formula (II);
申请公布号 US9023888(B2) 申请公布日期 2015.05.05
申请号 US201113983492 申请日期 2011.08.19
申请人 发明人 Reynolds Max
分类号 A61K31/35;A61K31/045;A61K31/047;A61K31/122;A61K31/125;A61K31/336;A61K31/343;A61K31/357;A61K31/015;A61K45/06;C07C15/085;C07C35/14;C07D493/08 主分类号 A61K31/35
代理机构 Ohlandt, Greeley, Ruggiero & Perle, L.L.P. 代理人 Ohlandt, Greeley, Ruggiero & Perle, L.L.P.
主权项 1. A composition comprising; (a) 30%-80% of at least one compound having the formula (I) wherein is or , but consecutive cannot be ; the cyclohexane ring may be saturated or unsaturated with any degree of unsaturation provided that when a attached to the ring is the ring carbon to which the is attached is unsaturated; one of R1, R2, R3, R4, R5, R6, R7, R8 or R9 is OH, and each of the remaining R1, R2, R3, R4, R5, R6, R7, R8 and R9 is H; o is 0 when the to which R1, R4, R5 or R9 is attached is and o is 1 when the to which R1, R4, R5 or R9 is ; wherein the at least two compounds of formula I consist essentially of terpinene-4-ol and α-terpineol; (b) 10% to 40% of at least one compound of formula (II) wherein is , or  but consecutive cannot be or the cyclohexane ring may be saturated or unsaturated with any degree of unsaturation provided that when a attached to the ring is or  the ring carbon to which the is attached is unsaturated; X is —O— or —O—O—; Y is —O— or —O—O— n is 0 or 1, m is 0 or 1, but n and m cannot both be 1 and neither n or m can be 1 if the attached to the ring is or R21, R22, R23, R24, R25, R26, R27, R28 or R29 are each independently selected from H, OH, OOH, OC═OR, OR; or an adjacent pair of R21, R22, R23, R24, R27 or R28 may join to form an epoxide or wherein any one of R22, R23, R27, R28 or R9 may further be ═O, provided that ═O is attached to an unsaturated carbon; o is 0 when the to which R21, R24 or R26 is attached is or  and o is 1 when the to which R21, R24 or R26 is and R is a C1 to C3 alkyl; wherein the at least one compound of formula 2 comprises between about 1% to about 4% 2-hydroxy-1,4-cineole; between about 5% to about 15% 1,4-dihydroxy-menth-2-ene; between about 0.5% to about 5% 1,2-dihydroxy-menth-3-ene and between about 1% to about 10% 1,2,4-trihydroxy-menthane; and (c) from 0 to 20% of at least one compound selected from the group consisting of an sesquiterpene, a sesquiterpene alcohol, a sesquiterpene epoxide, p-cymene, an oxygenated cyclohexane, a oxygenated cyclohexene and a monoterpene, wherein the amount of any monoterpenes in the fraction does not exceed 5% of the total composition.
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