Methods for restoration of histamine balance

摘要

Several embodiments provided herein relate to histamine dosing regimens are and uses of such regimens in the restoration of histamine balance in subjects suffering from, for example, histapenia and/or histadelia. Several embodiments also relate to the use of histamine dosing regimens for the treatment and/or prevention of migraine headaches.

主权项

1. A method for restoring histamine balance in a subject to treat histadelia or histapenia by normalizing activity of histamine receptors through multiple doses of a histamine composition administered in successive therapy segments, comprising:
administering to said subject an escalating dosing regimen comprising: a first dosing segment comprising two or more sequential doses of a histamine receptor activator said composition separated by a first time interval,
wherein the histamine receptor activator said composition comprises a histamine salt selected from the group consisting of histamine diphosphate, histamine phosphate, and histamine dihydrochloride,wherein the doses increase in histamine receptor activator said composition concentration from dose to dose while the administered volume of each dose stays constant; and a second dosing segment comprising two or more sequential doses of a histamine receptor activator said composition separated by a second time interval, wherein the doses increase in histamine receptor activator concentration from dose to dose while the administered volume of each dose stays constant; wherein the volume of each histamine receptor activator said composition dose in the second dosing segment is greater than the volume of each histamine receptor activator said composition dose in the first dosing segment, and the second time interval is longer than the first time interval.