Use of MicroRNA for treating diseases associated with a dysfunction of the cilia in multiciliated epithelial cells

摘要

The present invention relates to a method for evaluating the regenerative and/or differentiation capacity of ciliated epithelial tissue in a vertebrate subject, in particular a mammal, preferably a human, and to the use of microRNA in treating illnesses associated with a dysfunction of multiciliated epithelial cells.

主权项

1. A method for the treatment of a disorder associated with a dysfunction of the cilia of a ciliated epithelial tissue, the method comprising the step of administering to a subject in need thereof a miRNA selected from the group consisting of hsa-miR-34a (SEQ ID NO: 38), hsa-miR-34b (SEQ ID NO: 39), hsa-miR-34c-5p (SEQ ID NO: 40), hsa-miR-449a (SEQ ID NO: 46), hsa-miR-449b (SEQ ID NO: 47), and hsa-miR-449c (SEQ ID NO: 201), wherein the disorder is selected from the group consisting of primary ciliopathies, situs invertus, male and female infertility, Alstrom syndrome, Bardet-Biedl syndrome, Meckel-Gruber syndrome, retinal degeneration, Senior-Løken syndrome or secondary ciliopathies, chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis, and respiratory infections of viral origin.