| 发明名称 | Treatment of 'IQ motif containing GTPase activating protein' (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP | ||
| 摘要 | The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of ‘IQ motif containing GTPase activating protein’ (IQGAP), in particular, by targeting natural antisense polynucleotides of ‘IQ motif containing GTPase activating protein’ (IQGAP). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IQGAP. | ||
| 申请公布号 | US9023822(B2) | 申请公布日期 | 2015.05.05 |
| 申请号 | US201013388817 | 申请日期 | 2010.08.25 |
| 申请人 | CuRNA, Inc. | 发明人 | Collard Joseph;Khorkova Sherman Olga;Coito Carlos |
| 分类号 | A61K48/00;A61K31/7088;C12N15/113 | 主分类号 | A61K48/00 |
| 代理机构 | CuRNA, Inc. | 代理人 | CuRNA, Inc. ;Browder Monte R. |
| 主权项 | 1. A method of upregulating a function of and/or the expression of an ‘IQ motif containing GTPase activating protein’ (IQGAP) polynucleotide selected from SEQ ID NO: 1 or a variant thereof in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one single stranded modified antisense oligonucleotide of 12 to 25 nucleotides in length that specifically targets a complementary region of a natural antisense polynucleotide of the ‘IQ motif containing GTPase activating protein’ (IQGAP) polynucleotide selected from SEQ ID NO: 2 ; thereby upregulating a function of and/or the expression of the ‘IQ motif containing GTPase activating protein’ (IQGAP) polynucleotide in patient cells or tissues in vivo or in vitro. | ||
| 地址 | Miami FL US | ||