发明名称 |
Bioactive alkaloid compositions and their medical uses |
摘要 |
The present invention relates to a novel alkaloid and novel bioactive alkaloid fractions derivable from Ribes preferably selected among Ribes Rubrum and Ribes nigrum; methods of manufacturing such bioactive Ribes alkaloid fractions and their use for the inhibition of IKK-β, PDE4 and/or PDE5 and in addition their promoting effect on mitochondrial biogenesis and function; their therapeutic or non-therapeutic applications as nutritive or medicinal products in the management of conditions associated with impaired mitochondrial function or IKK-β, PDE4 and/or PDE5 activity, such as inflammation, neurodegeneration, dyslipidemia, type 2 diabetes mellitus, impaired wound healing, sarcopenia and other conditions associated with muscle dysfunction or tiredness and fatigue, or where optimization of muscular or cognitive function is desired; extracts, juices or concentrates of Ribes comprising such alkaloids; compostions comprising such alkaloids, including pharmaceutical compositions, nutritive product such as functional foods and nutraceutical compositions, and cosmetic compositions and medical devices. |
申请公布号 |
US9023816(B2) |
申请公布日期 |
2015.05.05 |
申请号 |
US201414330174 |
申请日期 |
2014.07.14 |
申请人 |
Asiros A/S |
发明人 |
Sloth Weidner Morten;Sloth Weidner Ida |
分类号 |
A61K31/7032;A61K36/185;C07H19/04;C07H15/18;A23L1/30;A61K31/185;C07H7/04;C07H19/044;C07H15/10 |
主分类号 |
A61K31/7032 |
代理机构 |
McLane, Graf, Raulerson & Middleton, PA |
代理人 |
McLane, Graf, Raulerson & Middleton, PA |
主权项 |
1. A method to aid in the treatment of a disease or condition selected from the group consisting of a dermatological disease, a cardiovascular disease, a dyslipidemic disorder, a pre-diabetic disorder, a wound, type 2 diabetes, metabolic syndrome, obesity, frailty, sarcopenia, osteoarthritis, an inflammatory disease, and diseases associated with mitochondrial dysfunction, the method comprising the step of administering to a subject having said disease or condition a composition comprising a juice or concentrate obtainable from Ribes rubrum and a juice or concentrate obtainable from Ribes nigrum. |
地址 |
Skovlunde DK |