发明名称 |
Peptides for the treatment of oxidative stress related disorders |
摘要 |
Isolated DJ-1 related peptides are disclosed and pharmaceutical compositions comprising same for treating oxidative stress-related disorder. |
申请公布号 |
US9023800(B2) |
申请公布日期 |
2015.05.05 |
申请号 |
US201213452986 |
申请日期 |
2012.04.23 |
申请人 |
Ramot at Tel-Aviv University Ltd. |
发明人 |
Offen Daniel;Lev Nirit;Melamed Eldad |
分类号 |
A61K38/00;A61K38/04;A01N61/00;A01N37/18;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating Parkinson's disease or Multiple Sclerosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a DJ-1 related peptide directly attached to a cell penetrating agent, wherein the amino acid sequence of said DJ-1-related peptide is as set forth in SEQ ID NO: 3, wherein when said cell penetrating agent is a peptide cell penetrating agent, the amino acid sequence of said peptide cell penetrating agent is selected from the group consisting of SEQ ID NOs: 21-23, thereby treating the Parkinson's disease or Multiple Sclerosis. |
地址 |
Tel-Aviv IL |