Intelligently controlled spectrometer methods and apparatus

摘要

The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching machenism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.

主权项

1. A method for operating a hyphenated instrument comprising:
a. conducting a first measurement of a sample using a first instrument with a first detector; b. generating a timing diagram based on the first measurement; c. adjusting an vacuum inlet structure of a second instrument according to the timing diagram; and d. conducting a second measurement of at least some part of the sample using the second instrument with a second different detector; wherein adjusting the vacuum inlet structure includes opening and/or closing the inlet.