| 主权项 |
1. A compound of the following formula or a pharmaceutically acceptable salt thereof: wherein: -A is independently -A1, -A3, or -A6; and —B is independently —B1, —B2, —B3, —B4, —B5, —B6, —B7, —B8, —B9, —B10, —B11, B12, —B13, or —B14; wherein:
-A1 is independently C5-12heteroaryl, and is optionally substituted with one or more groups selected from: —F, —Cl, —Br, —I, —RZ1,—CF3, —OH, —ORZ1, —OCF3, —SRZ1, —NH2, —NHRZ1, —NRZ12, pyrrolidino, piperidino, morpholino, piperizino, (N—C1-4alkyl)-piperizino, —C(═O)OH, —C(═O)ORZ1, —C(═O)RZ1, —OC(═O)RZ1, —C(═O)NH2, —C(═O)NHRZ1, —C(═O)NRZ12, —C(═O)-pyrrolidino, —C(═O)-piperidino, —C(═O)-morpholino, —C(═O)-piperizino, —C(═O)—(N—C1-4alkyl)-piperizino, —NHC(═O)RZ1, —NRZ1C(═O)RZ1, —OC(═O)NH2, —OC(═O)NHRZ1, —OC(═O)NRZ12, —OC(═O)-pyrrolidino, —OC(═O)-piperidino, —OC(═O)-morpholino, —OC(═O)-piperizino, (N—C1-4alkyl)-piperizino, —NHC(═O)ORZ1, —NRZ1C(═O)ORZ1, —NHC(═O)NH2, —NHC(═O)NHRZ1, —NHC(═O)NRZ12, —NHC(═O)-pyrrolidino, —NHC(═O)-piperidino, —NHC(═O)-morpholino, —NHC(═O)-piperizino, —NHC(═O)—(N—C1-4alkyl)-piperizino, —NO2, and —CN;
wherein each —RZ1 is independently saturated aliphatic C1-4alkyl, aliphatic C3-6alkynyl, saturated C3-6cycloalkyl, C5-6heteroaryl, -Ph, or —CH2-Ph,wherein each of said C3-6cycloalkyl, C5-6heteroaryl, and -Ph is optionally substituted with one or more substituents selected from —F, —Cl, —Br, —I, —RZ1A, —CF3, —OH, —ORZ1A, and —OCF3,wherein each —RZ1A is independently saturated aliphatic C1-4alkyl;and additionally wherein two adjacent substituents may together form —O—CH2—O— or —O—CH2CH2—O—;-A3 is independently imidamido or substituted imidamido;-A6 is independently aliphatic C2-6alkenyl, and is optionally substituted with one or more groups selected from: —F, —Cl, —Br, —I, —RZ6A, —CF3, —OH, —ORZ6A, —OCF3, —SRZ6A, —NH2, —NHRZ6A, —NRZ6A2, pyrrolidino, piperidino, morpholino, piperizino, (N—C1-4alkyl)-piperizino, —C(═O)OH, —C(═O)ORZ6A, —C(═O)RZ6A, —OC(═O)RZ6A, —C(═O)NH2, —C(═O)NHRZ6A, —C(═O)NRZ6A2, —C(═O)-pyrrolidino, —C(═O)-piperidino, —C(═O)-morpholino, —C(═O)-piperizino, —C(═O)—(N—C1-4alkyl)-piperizino, —NHC(═O)RZ6A, —NRZ6AC(═O)RZ6A, —OC(═O)NH2, —OC(═O)NHRZ6A, —OC(═O)NRZ6A2, —OC(═O)-pyrrolidino, —OC(═O)-piperidino, —OC(═O)-morpholino, —OC(═O)-piperizino, (N—C1-4alkyl)-piperizino, —NHC(═O)ORZ6A, —NRZ6AC(═O)ORZ6A, —NHC(═O)NH2, —NHC(═O)NHRZ6A, —NHC(═O)NRZ6A2, —NHC(═O)-pyrrolidino, —NHC(═O)-piperidino, —NHC(═O)-morpholino, —NHC(═O)-piperizino, —NHC(═O)—(N—C1-4alkyl)-piperizino, —NO2, and —CN,
wherein each —RZ6A is independently saturated aliphatic C1-4alkyl, saturated C3-6cycloalkyl, -Ph, or —CH2-Ph,wherein each C3-6cycloalkyl and -Ph is optionally substituted with one or more substituents selected from —F, —Cl, —Br, —I, —RZ6B, —CF3, —OH, —ORZ6B, and —OCF3,wherein each —RZ6B is independently saturated aliphatic C1-4alkyl; and wherein:
—B1 is independently saturated aliphatic C1-6alkyl;—B2 is independently aliphatic C2-6alkynyl;—B3 is independently mercapto-C1-4alkyl, sulfanyl-C1-4alkyl, sulfinyl-C1-4alkyl, or sulfonyl-C1-4alkyl;—B4 is independently hydroxy-C1-4alkyl or ether-C1-4alkyl;—B5 is independently phenyl-C1-6alkyl or C5-6heteroaryl-C1-6alkyl, and is optionally substituted with one or more groups selected from: —F, —Cl, —Br, —I, —RY5A, —CF3, —OH, —ORY5A, —OCF3, —SRY5A , —NH2, —NHRY5A, —NRY5A2, pyrrolidino, piperidino, morpholino, piperizino, (N—C1-4alkyl)-piperizino, —C(═O)OH, —C(═O)ORY5A, —C(═O)RY5A, —OC(═O)RY5A, —C(═O)NH2, —C(═O)NHRY5A, —C(═O)NRY5A2, —C(═O)-pyrrolidino, —C(═O)-piperidino, —C(═O)-morpholino, —C(═O)-piperizino, —C(═O)—(N—C1-4alkyl)-piperizino, —NHC(═O)RY5A, —NRY5AC(═O)RY5A, —OC(═O)NH2, —OC(═O)NHRY5A, —OC(═O)NRY5A2, —OC(═O)-pyrrolidino, —OC(═O)-piperidino, —OC(═O)-morpholino, —OC(═O)-piperizino, (N—C1-4 alkyl)-piperizino, —NHC(═O)ORY5A, —NRY5AC(═O)ORY5A, —NHC (═O)NH2, —NHC(═O)NHRY5A, —NHC(═O)NRY5A2, —NHC(═O)-pyrrolidino, —NHC(═O)-piperidino, —NHC(═O)-morpholino, —NHC(═O)-piperizino, —NHC(═O)—(N—C1-4alkyl)-piperizino, —NO2, and —CN,
wherein each —RY5A is independently saturated aliphatic C1-4alkyl, saturated C3-6cycloalkyl, -Ph, or —CH2-Ph,wherein each of said C3-6cycloalkyl and -Ph is optionally substituted with one or more substituents selected from —F, —Cl, —Br, —I, —RY5B, —CF3, —OH, —ORY5B, and —OCF3,wherein each —RY5B is independently saturated aliphatic C1-4alkyl;—B6 is independently acyl-C1-6alkyl, carboxy-C1-6alkyl, oxyacyl-C1-6alkyl, or acyloxy-C1-6alkyl;—B7 is independently amido-C1-4alkyl or substituted amido-C1-4alkyl;—B8 is independently C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C3-6heterocyclyl, or C3-6heterocyclyl-C1-4alkyl, and is optionally substituted with one or more groups selected from: —F, —Cl, —Br, —I, —RY8A, —CF3, —OH, —ORY8A, —OCF3, —NH2, —NHRY8A, —NRY8A2, pyrrolidino piperidino, morpholino, piperizino, (N—C1-4alkyl)-piperizino, —C(═O)OH, —C(═O)ORY8A, —C(═O)RY8A, —OC(═O)RY8A, —C(═O)NH2, —C(═O)NHRY8A, —C(═O)NRY8A2, —C(═O)-pyrrolidino, —C(═O)-piperidino, —C(═O)-morpholino, —C(═O)-piperizino, —C(═O)—(N—C1-4alkyl)-piperizino, —NHC(═O)RY8A, —NRY8AC(═O)RY8A, and —CN;
wherein each —RY8A is independently saturated aliphatic C1-4alkyl, saturated C3-6cycloalkyl, -Ph, or —CH2-Ph,wherein each of said C3-6cycloalkyl and -Ph is optionally substituted with one or more substituents selected from —F, —Cl, —Br, —I, —RY8B, —CF3, —OH, —ORY8B, and —OCF3,wherein each —RY8B is independently saturated aliphatic C1-4alkyl;—B9 is independently halo-C1-6alkyl;—B10 is independently nitro-C1-6alkyl;—B11 is independently cyano-C1-6alkyl;—B12 is independently phosphate-C1-6alkyl;—B13 is independently carbamate-C1-6alkyl; and—B14 is independently oxime-C1-6alkyl. |
