Synthesis of 18F-labeled tracers in hydrous organic solvents

摘要

A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.

主权项

1. A method for synthesizing an 18F-labeled probe the method comprising:
(1) eluting an amount of 18F with a first solvent comprising a predetermined amount of water and at least one organic polar aprotic solvent, but no organic erotic solvents, the 18F eluting as an 18F solution, the predetermined amount of water being in a range of about 0.1 vol % to about 5.0 vol %; and (2) using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe; wherein the at least one labeling reagent comprises K2CO3, KHCO3, Cs2CO3, potassium mesylate, potassium oxylate, or tetrabutylammonium bicarbonate; wherein the water content of the 18F solution during 18F-labeling is in a range of about 0.1 vol % to about 2.0 vol %; and wherein there is no step of drying the 18F solution starting from a time when the eluting is performed and ending at a time when the 18F-labeling is performed.