发明名称 Therapeutic compounds
摘要 The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by GPCRs and/or RSKs.
申请公布号 US9024071(B2) 申请公布日期 2015.05.05
申请号 US201013318877 申请日期 2010.05.05
申请人 University of Florida Research Foundation, Inc. 发明人 Booth Raymond G.
分类号 C07C211/00;C07C211/42;A61K31/13 主分类号 C07C211/00
代理机构 Edwards Wildman Palmer LLP 代理人 Edwards Wildman Palmer LLP ;Corless Peter F.;Hsi Jeffrey D.
主权项 1. A compound of formula (I):wherein, R1 is independently, NH2, NH(R′), N(R′)2; or  wherein ring A is a 3-8 membered heterocyclic or heteroaryl, containing 0-3 additional heteroatoms selected from O, N and S; wherein ring A is optionally substituted; each R′ is independently alkyl, alkenyl, or alkynyl, each of which may be optionally substituted; R2 is independently —(CH2)n—; each n is independently 1 or 2; R3 is independently H, OH, or halo; R4 is independently H, OH, or halo each R5 is independently alkyl, aryl, halo, nitro, amino, heteroaryl, cycloalkyl, heterocyclic, or a alkoxy; R6 is independently H or alkyl; R7 independently H, or N(alkyl)2; and each R8 is independently cycloalkyl or heterocyclic, optionally substituted with 1, 2, 3, or 4 independent R5;or salt thereof.
地址 Gainesville FL US