发明名称 |
Cell-permeable peptide |
摘要 |
The present invention relates to a novel human-derived cell permeable peptide-bioactive peptide conjugate and the use thereof. According to the present invention, cationic cell permeable peptides derived from human bone morphogenetic protein-4 have no toxicity and immunogenicity and thus exhibit high stability as compared to viral peptide delivery vehicles, and can transport cell impermeable material into cells and into an organism without any damage to cell or material, thereby significantly increasing target gene expression. In addition, the peptide may be applied to clinical use without having to undergo a large number of processes and mass-produced, such that the present invention may be useful in the development of a drug delivery system and treatment technologies using said peptide. |
申请公布号 |
US9023987(B2) |
申请公布日期 |
2015.05.05 |
申请号 |
US201113821790 |
申请日期 |
2011.04.25 |
申请人 |
Seoul National University R&DB Foundation;Nano Intelligent Biomedical Engineering Corporation Co., Ltd. |
发明人 |
Chung Chong-Pyoung;Park Yoon-Jeong;Lee Jue-Yeon;Suh Jin Sook |
分类号 |
C07K9/00;C07K14/435;C07K14/51;C07K7/06;C07K7/08;A61K38/00 |
主分类号 |
C07K9/00 |
代理机构 |
Hultquist, PLLC |
代理人 |
Hultquist, PLLC ;Hultquist Steven J.;Grant Mary B. |
主权项 |
1. An isolated cell permeable peptide consisting of the amino acid sequence set forth in SEQ ID NO. 1. |
地址 |
Seoul KR |