| 发明名称 | Charged-balanced imaging agents | ||
| 摘要 | The present invention relates to compositions and methods of optically imaging tissues or cells using imaging agents have in vivo properties that result in signal-to-background ratios of at least about 1:1. TL is a targeting ligand and n is −1, 0 or +1.; | ||
| 申请公布号 | US9023611(B2) | 申请公布日期 | 2015.05.05 |
| 申请号 | US201013148137 | 申请日期 | 2010.02.05 |
| 申请人 | Beth Israel Deaconess Medical Center;Georgia State University Research Foundation, Inc. | 发明人 | Frangioni John V.;Henary Maged M. |
| 分类号 | C12Q1/02;C07D209/02;A61K49/00;C07D255/02;A61B6/00;C09B23/01;C09B23/08 | 主分类号 | C12Q1/02 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Corless Peter F. |
| 主权项 | 1. A method of imaging tissue or cells, the method comprising: (a) contacting the tissue or cells with an imaging agent comprising a dye; (b) irradiating the tissue or cells at a wavelength absorbed by the dye; (c) detecting an optical signal from the irradiated tissue or cells, wherein the signal-to-background ratio of the detected optical signal is at least about 1.1, thereby imaging the tissue or cells; wherein the dye has the formula X:or an ester thereof, which permits covalent conjugation of the fluorophore to targeting ligands. | ||
| 地址 | Boston MA US | ||