| 发明名称 | Method of regulating NFATc2 activity in lymphocytes | ||
| 摘要 | A method of decreasing NFATc2 activity in a lymphocyte includes administering to the lymphocyte an amount of an NFATc2 mRNA antagonist that binds to a binding site on the 3′UTR of NFATc2 mRNA effective to decrease the activity of NFATc2 mRNA in the lymphocyte. | ||
| 申请公布号 | US9023829(B2) | 申请公布日期 | 2015.05.05 |
| 申请号 | US201113047295 | 申请日期 | 2011.03.14 |
| 申请人 | Case Western Reserve University | 发明人 | Laughlin Mary J. |
| 分类号 | A01N43/04;A61K31/7105;C12N5/0783;A61K35/12 | 主分类号 | A01N43/04 |
| 代理机构 | Tarolli, Sundheim, Covell & Tummino LLP | 代理人 | Tarolli, Sundheim, Covell & Tummino LLP |
| 主权项 | 1. A method of decreasing NFATc2 activity in a lymphocyte, comprising administering to the lymphocyte an amount of an NFATc2 mRNA antagonist that binds to a binding site on the 3′UTR of NFATc2 mRNA effective to decrease the activity of NFATc2 mRNA in the lymphocyte, the NFATc2 mRNA antagonist comprising microRNA having a nucleotide sequence substantially homologous to SEQ ID NO: 1. | ||
| 地址 | Cleveland OH US | ||