Surface treatment for a medical device

摘要

A surface coating for a medical device is provided that may prevent or slow the formation of medical biofilms on the surface of the device. Covalent attachment of certain analogues of N-acyl L-homoserine lactones onto a medical device may provide the advantage of slowing biofilm formation in a manner that is targeted to the surface of the medical device and not the patient. Such a device may allow healthcare providers to prevent bacterial buildups on the surfaces of the device, which may lead to biofilm formation.

主权项

1. An airway device comprising:
a conduit for insertion into a patient's trachea; and an acyl-homoserine lactone analog comprising a hydrocarbon tether covalently bound directly to a surface of the conduit, wherein the acyl-homoserine lactone analog is a non-microbicidal compound configured to interrupt bacterial communication to reduce biofilm formation on the conduit when the conduit is inserted into the trachea, and wherein the conduit which is covalently bound to the acyl-homoserine lactone analog comprising a hydrocarbon tether has a Formula (II),  and wherein n or m is any number greater than 1.