发明名称 |
ARYLETHYNYL DERIVATIVES |
摘要 |
The present invention relates to ethynyl derivatives of formula (I) wherein R1 is phenyl, 3-fluorophenyl, 4-fluorophenyl or 2,5-di-fluorophenyl; or to a pharmaceutically acceptable acid addition salt, in enantiomerically pure form with the absolute configuration as shown in formula I. It has now surprisingly been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5) which show advantageous biochemical-, physicochemical- and pharmacodynamic- properties compared to compounds of prior art. |
申请公布号 |
PH12015500538(B1) |
申请公布日期 |
2015.05.04 |
申请号 |
PH12015500538 |
申请日期 |
2015.03.12 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
JAESCHKE, GEORG;LINDEMANN, LOTHAR;STADLER, HEINZ;VIEIRA, ERIC |
分类号 |
A61K31/444;A61K31/536;A61P1/08;A61P9/10;A61P13/10;A61P21/00;A61P25/04;A61P25/06;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/34;A61P25/36;A61P27/02;A61P43/00;C07D413/04 |
主分类号 |
A61K31/444 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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