A NEW PROCESS FOR THE SYNTHESIS OF HIV PROTEASE INHIBITORS

摘要

The invention relates to a novel process for the synthesis of HIV protease inhibitors. More particularly, the invention relates to the synthesis of HIV protease inhibitorssuch as AmprenavirFosamprenavir,Darunavir and sequinavirvia synazido epoxide with high enantiomeric excessas a common intermediateobtained by Co-catalyzed hydrolytic kinetic resolution of anti-(2SR, 3SR)-3-azido-4-phenyl-l, 2-epoxybutane.