SIMIAN SUBFAMILY C ADENOVIRUSES SAdV-40, -31, AND -34, AND USES THEREOF

摘要

PROBLEM TO BE SOLVED: To provide recombinant adenovirus vectors which effectively deliver molecules to a target and minimize effect of pre-existing immunity to selected adenovirus serotypes in a population.SOLUTION: The present invention relates to: a recombinant vector that comprises simian adenovirus SAdV-40, SAdV-31 or SAdV-34 sequences and a heterologous gene under the control of regulatory sequences; cell lines which express simian adenovirus SAdV-40, SAdV-31 or SAdV-34 gene(s); and methods of using the vectors and cell lines.