摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a production method which inexpensively produces a hydroxyproline derivative useful as a raw material of a medicine and an agricultural chemical by using an inexpensive raw material at high yield, and is suitable for industrial production. <P>SOLUTION: The hydroxyproline derivative expressed by a general formula (2) is produced by N-acylating hydroxyproline in the co-existence of at least one of bases selected from an alkali metal carbonate, an alkali earth metal carbonate, an alkali metal bicarbonate and an alkali earth metal bicarbonate. In the formula, R<SP POS="POST">1</SP>denotes 1C-6C alkyl, aryl or aralkyl, and R<SP POS="POST">2</SP>denotes 1C-6C alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl or aralkyloxycarbonyl. <P>COPYRIGHT: (C)2012,JPO&INPIT</p> |