Insulin-Like Growth Factor-1 Receptor Inhibitors

摘要

The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating Insulin-Like-Growth Factor I Receptor and Insulin Receptor. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.

主权项

1. A compound represented by Formula I: wherein: R1 is H, halo, or CN; R2 is Ring A is phenyl or a 5 or 6-membered heteroaryl, which can be optionally substituted with one to three moieties selected from C1-C3 alkyl, C1-C3 haloalkyl, OR3, N(Ra)2 and halo; Ring B is phenyl or a 5 or 6-membered heteroaryl, which can be optionally substituted with one to three moieties selected from C1-C3 alkyl, C1-C3 haloalkyl, OR3, N(Ra)2 and halo; Ring C is a 10-membered fused bicyclic aryl or heteroaryl, which can be optionally substituted with one to three moieties selected from C1-C3 alkyl and halo; W is independently H or C1-C3 alkyl; R3 is H, C1-C3 haloalkyl or C1-C3 alkyl; Or a pharmaceutically acceptable salt thereof.