Disclosed herein are linear donor molecules comprising homology arms of 50-750 base pairs (e.g., 50-100 base pairs) flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
申请公布号
AU2009238629(C1)
申请公布日期
2015.04.30
申请号
AU20090238629
申请日期
2009.04.13
申请人
SANGAMO BIOSCIENCES, INC.
发明人
URNOV, FYODOR;DEKELVER, RUSSELL;GREGORY, PHILIP D.;HOLMES, MICHAEL C.