HETEROCYCLIC COMPOUND

摘要

A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula:;;wherein each symbol is as defined herein,
or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent the prophylaxis or treatment of diabetes mellitus are provided.

主权项

1. A compound represented by the following formula: wherein ring A represents an optionally substituted benzene ring or an optionally substituted heterocyclic ring; ring B represents a 6-membered nitrogen-containing heterocyclic ring optionally further substituted by 1 to 3 substituents selected from a halogen atom and a C1-6 alkyl group; X1, X2, X3, and X4 each independently represent a carbon atom or a nitrogen atom; n represents an integer of 1 to 4; R1 represents -L1-L2-COR4, an optionally substituted tetrazolyl group, or an optionally substituted dihydrooxadiazolyl group; L1 represents a bond, —O—, —S—, —SO—, —SO2—, or —NR5—; L2 represents a bond or an optionally substituted C1-3 alkylene group; R2 and R3 each independently represent a hydrogen atom or a C1-6 alkyl group; R4 represents NR6R7 or OR8; and R5, R6, R7, and R8 each independently represent a hydrogen atom or an optionally substituted C1-6 alkyl group, or a salt thereof.