Methods of Preparing Ophthalmic Formulations and Uses of Same

摘要

The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof:;;Values and preferred values of the variables in structural Formula (I) are described herein.

主权项

1. A process for preparing an ophthalmic ointment, comprising:
(a) combining a fluorescent molecular rotor compound with mineral oil as a levigating agent, thereby obtaining a first mixture; (b) subjecting the first mixture to ball milling agitation with a grinding media, thereby obtaining a second mixture; and (c) combining the second mixture with a hydrophobic vehicle, thereby obtaining an ointment.