发明名称 Process to produce atorvastatin intermediates
摘要 <p>The invention provides a process for the production of 1 a compound of formula (I), said process comprising reacting a compound of formula (II), with a compound of formula (III), wherein R1 and R2 may be the same or different and are selected from H; a C1-C6 alkyl which may be straight or branched, substituted or unsubstituted; or R1 and R2 together represent an alkylidene group of the formula CRaRb wherein Ra and Rb may be the same or different and are selected from an alkyl group having between 1 and 6 atoms, and wherein R3 represents a C1-C6 alkyl group, wherein the reaction is carried out in the presence of a base. Using a base may advantageously allow a lower temperature and/or may result in a higher yield. Also, a phase separation step may be omitted.</p>
申请公布号 IL237335(D0) 申请公布日期 2015.04.30
申请号 IL20150237335 申请日期 2015.02.19
申请人 DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. 发明人
分类号 C07D 主分类号 C07D
代理机构 代理人
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