Bioactive Agent Delivery Devices and Methods of Making and Using the Same

摘要

A method of preparing a substantially planar microdevice comprising a plurality of reservoirs is provided. In general, the method comprises forming a plurality of microdevices comprising a plurality of reservoirs from a planar layer of a biocompatible polymer. The method also comprises depositing one or more bioactive agents into the reservoirs. The microdevice is configured to attach to a target tissue and release the bioactive agent in close proximity to the tissue.

主权项

1. A method of preparing a substantially planar microdevice comprising a plurality of reservoirs, the method comprising:
fabricating a planar layer of a biocompatible polymer on a substrate; defining a microdevice structure in the planar layer using successive deposition of photoresist layer, light exposure, and etching; and introducing a plurality of reservoirs in the microdevice structure using successive deposition of photoresist layer, light exposure, and partial etching, thereby producing a planar microdevice comprising a plurality of reservoirs, wherein the plurality of reservoirs are open at a first surface of the microdevice and are closed at the second surface of the microdevice.