| 发明名称 |
METHODS FOR REMOVING TRIAZINE FROM N-METHYLIMIDAZOLE FOR SYNTHESIS OF OLIGONUCLEOTIDE |
| 摘要 |
Methods for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a N-methylimidazole and methods for making oligonucleotides using N-methylimidazole are provided. In one embodiment, a method for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a feedstock containing N-methylimidazole includes contacting the feedstock with small or medium pore molecular sieves. The small or medium pore molecular sieves adsorb 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from the feedstock. The method further includes separating the small or medium pore molecular sieves from the feedstock. |
| 申请公布号 |
US2015119564(A1) |
申请公布日期 |
2015.04.30 |
| 申请号 |
US201414471635 |
申请日期 |
2014.08.28 |
| 申请人 |
Honeywell International Inc. |
发明人 |
Mohan Venkatraman;Lorenz Sandra M.;Gajda Gregory |
| 分类号 |
C07D233/58;C07H21/04;C07H1/00 |
主分类号 |
C07D233/58 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a feedstock containing N-methylimidazole, the method comprising:
contacting the feedstock with small or medium pore molecular sieves, wherein the small or medium pore molecular sieves adsorb 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from the feedstock; and separating the small or medium pore molecular sieves from the feedstock. |
| 地址 |
Morristown NJ US |
