发明名称 Method of drug loading in cell-derived membrane vesicles by engineering parent cells with membrane fusogenic liposomes and drug delivery method using thereof
摘要 The present invention relates to a membrane vesicle in which a prepared drug is included using a membrane fusogenic liposome (MFL), a membrane vesicle preparation method, and a drug delivery method using the membrane vesicle. Specifically, the membrane vesicle of the present invention allows hydrophilic and hydrophobic drugs to be simultaneously included therein, is isolated from a cell to facilitate more efficient and selective drug delivery to neighboring cells, and is safe as a nanomaterial derived from a living body, and a step for directly entrapping the drug in the membrane vesicle is unnecessary. Therefore, the membrane vesicle can be effectively used for preventing and treating a variety of cancers and degenerative diseases in which the membrane vesicle is known to play an important role.
申请公布号 KR20150046709(A) 申请公布日期 2015.04.30
申请号 KR20140032446 申请日期 2014.03.20
申请人 한국과학기술원 发明人 박지호;이준성;김지영
分类号 A61K9/127;A61K47/30;A61K47/48 主分类号 A61K9/127
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