ANTIBODY ARRAY USED FOR THE ANALYSIS OF THE THREE-DIMENSIONAL STRUCTURE OF PROTEIN THERAPEUTICS AND ITS PRODUCTION

摘要

This invention relates to an antibody array for the analysis of the three-dimensional structure of a protein. It includes the development and production of the antibody array and methods of using the array to analyze the three-dimensional structure of a protein as well as to compare the three-dimensional structure of two proteins, for example, a therapeutic protein and a biosimilar, to determine if the two proteins are similar.

主权项

1. A method of determining the conformational or 3-dimensional structure of a protein comprising: contacting said protein with an array of antibodies that specifically bind to epitopes that cover the surface of said protein; and measuring the quantity of complex formed between each antibody specifically bound to said protein.