D-AMINO ACID PHOSPHORAMIDATE AND D-ALANINE THIOPHOSPHORAMIDATE PRONUCLEOTIDES OF NUCLEOSIDE COMPOUNDS USEFUL FOR THE TREATMENT OF HCV

摘要

Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are of Formula AI or 1001 or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof.