发明名称 |
Method for producing antibody molecules having inter-species, intra-target cross-reactivity |
摘要 |
<p>A method is disclosed for producing an antibody molecule having inter-species, intra-target cross-reactivity. The method comprises the steps of creating a first immune library for a target antigen from a first species, for example man; combining variable regions from the first immune library in a chain shuffling protocol, to produce a second immune library; and screening the second immune library for affinity to both the target antigen and a corresponding antigen from a second species. The second species is different from the first species. By using a suitable test animal as the second species, the method paves the way to convenient testing of the antibody molecule.</p> |
申请公布号 |
AU2013310924(A8) |
申请公布日期 |
2015.04.30 |
申请号 |
AU20130310924 |
申请日期 |
2013.08.30 |
申请人 |
ARGEN-X NV |
发明人 |
DE HAARD, JOHANNES JOSEPH WILHELMUS;BLANCHETOT, CHRISTOPHE FREDERIC JEROME;VAN DER WONING, SEBASTIAN PAUL |
分类号 |
C07K16/28;C12N15/10;C40B40/08 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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