发明名称 |
Process for the preparation of 3-difluoromethyl-1-methyl-1h-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide which involves 6,6-dichlorofulven and intermediates obtained in said process |
摘要 |
<p>The invention relates to a process for the preparation of formula (I) which process comprises a) reacting a compound of formula (II), wherein X is chloro or bromo, with an organometallic species to (III), wherein X is chloro or bromo; reacting the halobenzyne with a fulvene (IV), to a compound of formula (V) wherein X is chloro or bromo; b) hydrogenating V in the presence of a suitable metal catalyst to a compound of formula (VI) wherein X is chloro or bromo; and either c1) reacting the compound of formula VI with NH3 in the presence of a catalyst comprising palladium and at least one ligand to the compound of formula (VII); and d) reacting the compound of formula VII in the presence of a base with a compound of formula (VIII), to the compound of formula I; or c2 reacting the compound of formula (VI) in the presence of a copper catalyst and a ligand with the compound of formula (VIIIa), to the compound of formula (I).</p> |
申请公布号 |
IL222401(A) |
申请公布日期 |
2015.04.30 |
申请号 |
IL20120222401 |
申请日期 |
2012.10.11 |
申请人 |
SYNGENTA PARTICIPATIONS AG |
发明人 |
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分类号 |
C07C;C07D |
主分类号 |
C07C |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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