RADIAL SHAPE OF POLYMER COMPOUND CONTAINING IODINE, PREPARATION METHOD THEREOF, AND CT CONTRAST MEDIUM COMPOSITION CONTAINING SAME

摘要

Disclosed herein is an iodine-containing radial-shaped macromolecule suitable for an active ingredient of the computed tomography (CT) contrast medium, a method to prepare the same, and a contrast medium composition including the same. With respect to the iodine-containing radial-shaped macromolecule according to the present invention, the duration of contrast enhancement has been significantly improved in comparison to that of the current small molecular contrast media compounds containing iodine, the in vivo toxicity has been reduced by forming a protective layer with relatively long biocompatible polymer chains which prevents the exposure of the toxic iodine-containing compounds substituted near the surface of the core region to the external environment for potential adverse effects, the in vivo circulation time has been increased by preventing rapid uptake by macrophages, the excretion is realized at the adequate time point after the intravascular injection, the large-scale production at high yield and low cost is amenable due to the simple preparation and purification methods, the reproducibility in terms of the preparation and effects is high due to the relatively low polydispersity, and the structural integrity of the iodine-containing radial-shaped macromolecules is firmly ensured because the compound is entirely formed by covalent bonds. Therefore, the iodine-containing radial-shaped macromolecule may be suitable for the preparation of a CT contrast medium.