COMPOSITION AND METHOD FOR TREATING NEUROLOGICAL DISEASE

摘要

Disclosed are compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, and one or more excipients, wherein at least one of the excipients modifies release of amantadine. Methods of administering the same are also provided.

主权项

1. A method comprising:
orally administering to a human subject with Parkinson's disease a once daily dose consisting of (i) 200 to 500 mg of a drug selected from the group consisting of amantadine and pharmaceutically acceptable salts thereof, and (ii) at least one excipient,
wherein at least one of said excipients is a release modifying excipient, andwherein at least 50% of said drug is in an extended release form, andwherein administration of the dose once daily provides a steady state plasma concentration of about 3 μM.