发明名称 |
TRIAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND /OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS |
摘要 |
<p>Compounds of the formula I:
or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted triazolyl, and R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X 3 and/or a P2X 2/3 receptor antagonists and methods of making the compounds.</p> |
申请公布号 |
EP2225213(B1) |
申请公布日期 |
2015.04.29 |
申请号 |
EP20080861017 |
申请日期 |
2008.12.08 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
CHEN, LI;DILLON, MICHAEL PATRICK;FENG, LICHUN;HAWLEY, RONALD CHARLES;YANG, MINMIN |
分类号 |
C07D249/06;A61K31/4192;A61K31/497;A61P11/00;A61P13/02;A61P29/00;C07D403/12;C07D403/14 |
主分类号 |
C07D249/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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