Certain embodiments are directed to methods and compounds for inhibiting UBE3A-ATS, the endogenous antisense transcript of ubiquitin protein ligase E3A (UBE3A). Such methods and compounds are useful for inducing expression of paternal UBE3A in cells and animals.
申请公布号
EP2864479(A2)
申请公布日期
2015.04.29
申请号
EP20130809694
申请日期
2013.06.25
申请人
ISIS PHARMACEUTICALS, INC.;BAYLOR COLLEGE OF MEDICINE