DOUBLE-STRANDED RIBONUCLEIC ACID WITH INCREASED EFFECTIVENESS IN AN ORGANISM

摘要

The present invention relates to a double-stranded ribonucleic acid (dsRNA) having improved stability in cells and biological fluids, wherein said dsRNA comprises an antisense RNA strand and a sense RNA strand, wherein said antisense RNA strand has a nucleotide sequence which is substantially complementary to a target RNA, wherein (a) one of said RNA strands comprises a 1 to 2 nucleotide overhang, (b) said dsRNA has one blunt end, and (c) said dsRNA comprises at least one chemically modified nucleotide.