摘要 |
The invention pertains to use of DGAT-1 inhibitors to treat and/or prevent overweight, obesity and various diseases and disorders associated therewith. Other conditions also can be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease. Compounds and compositions suitable for use in the disclosed methods are also provided. |
申请人 |
METABASIS THERAPEUTICS, INC. |
发明人 |
REDDY, K. RAJA;STEBBINS, JEFF;BOYER, SERGE, H.;ERION, MARK, D.;HECKER, SCOTT, J.;RAFFAELE, NICHOLAS, BRIAN;BOOKSER, BRETT, C.;REDDY, MALI, VENKAT |