Anti-FcRH5 antibodies and immunoconjugates and methods of use

摘要

A method of determining the presence of FcRH5 in a biological sample suspected of containing FcRH5 is provided comprising exposing the biological sample to an isolated monoclonal anti-FcRH5 antibody.

主权项

1. A method of determining the presence of FcRH5 in a biological sample suspected of containing FcRH5, said method comprising exposing said sample to an isolated monoclonal anti-FcRH5 antibody comprising:
(a) a light chain variable domain comprising:
(i) HVR-L1 comprising the sequence KASQNVGSNVA (SEQ ID NO: 28);(ii) HVR-L2 comprising the sequence SASYRYS (SEQ ID NO: 29); and(iii) HVR-L3 comprising the sequence QQYKTWT (SEQ ID NO: 30); and (b) a heavy chain variable domain comprising:
(i) HVR-H1 comprising the sequence GYTFTNYGMN (SEQ ID NO: 37) or GYTFTNYGIN (amino acid residues 26-35 of SEQ ID NO:22);(ii) HVR-H2 comprising the sequence NTYTGEPTYTDDFKG (SEQ ID NO: 38); and(iii) HVR-H3 comprising the sequence ARRSIPYYYAMDY (SEQ ID NO: 39), anddetermining binding of said antibody to FcRH5 in said sample wherein binding of said antibody to FcRH5 in said sample is indicative of the presence of FcRH5 in said sample.