HIV-1 latency model for high throughput screening

摘要

Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I derived vector pro virus, which upon activation expresses a marker for late viral gene expression due to the insertion of the marker gene in the position of HIV-I envelope.

主权项

1. An isolated, latently infected T cell line harboring a latent HIV-I derived vector pro virus, which upon activation of the pro virus expresses a secretable marker for late viral gene expression, the gene for said marker being inserted in the position of HIV-I envelope.