| 摘要 |
The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, actinic keratosis. |
| 主权项 |
1. A method for the treatment of skin having wrinkles, the method comprising topically administering, to a subject in need thereof, a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt thereof,wherein:
R1 is —(CH2)aY or —CH═CH—(CH2)pY; Y is —SO3H, —SO3−.X+, or —SO3R3; X+ is an organic cation or an inorganic cation, such that the general charge of the compound of Formula (I) is neutral; R9 and R9′ are independently selected from —OH and —OR2, wherein when R9 and R9′ are both —OR2, then said R9 and R9′ can be the same or different; R2 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkylsulfonyl group, a substituted or unsubstituted arylsulfonyl group, a substituted or unsubstituted alkylcarbonyl group or a substituted or unsubstituted arylcarbonyl group; R3 is a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; a is a number selected from 0, 1, 2, 3, 4, 5 and 6; and p is a number selected from 0, 1, 2, 3, 4, 5 and 6, wherein the 2,5-dihydroxybenzene derivative is administered in an amount effective to reduce skin wrinkles. |
