| 发明名称 | Highly effective anti-cadherin antibody for induction of antibody-dependent cellular cytotoxicity in vivo | ||
| 摘要 | It is an object of the present invention to provide an anti-cadherin antibody having high antibody-dependent cellular cytotoxicity. The present invention provides an anti-cadherin antibody, which recognizes any one of an upstream region of EC1, a cadherin domain 4 (EC4) and a cadherin domain 5 (EC5), wherein an antibody-dependent cellular cytotoxicity at an antibody concentration of 1 μg/mL is 30% or more. | ||
| 申请公布号 | US9017683(B2) | 申请公布日期 | 2015.04.28 |
| 申请号 | US201313886766 | 申请日期 | 2013.05.03 |
| 申请人 | The University of Tokyo;Perseus Proteomics Inc. | 发明人 | Aburatani Hiroyuki;Zhang Lilin;Ishii Keisuke;Kouda Katsushi;Sakamoto Aya;Katsumi Keiko;Onishi Hiroshi;Kayukawa Yoko |
| 分类号 | A61K39/395;C07K16/30;A61P35/00;C07K16/28;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Birch, Stewart, Kolasch & Birch, LLP | 代理人 | Birch, Stewart, Kolasch & Birch, LLP |
| 主权项 | 1. A method for lysing cancer cells that express P-cadherin in a human subject, comprising administering to said subject a cytotoxic agent, wherein the cytotoxic agent comprises the antibody produced from the hybridoma PPMX12, Accession No. NITE BP-865, or an antigen-binding fragment thereof, wherein said antigen binding fragment is fused to an antibody Fc region. | ||
| 地址 | Tokyo JP | ||