Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins

摘要

Compositions and methods utilizing immunomodulating agents can either stimulate or indirectly augment the immune system or have an immunosuppressive effect. TNFR25 agonists disclosed herein have an anti-inflammatory and healing effect. They can be used to treat disease caused by asthma and chronic inflammation such as inflammatory bowel diseases including ulcerative colitis and Crohn's Disease. TNFR25 antagonists disclosed herein are capable of inhibiting CD8 T cell-mediated cellular immune responses and can for example, mitigate organ or tissue rejection following a tissue transplantation.

主权项

1. A method for enhancing expansion of antigen-specific CD8 T cells in a subject, the method comprising the steps of:
(a) administering to the subject (i) an antigenic composition comprising a cell expressing a cognate antigen of the antigen specific CD8 T cells, wherein the cognate antigen is a non-self antigen; and (ii) an immunostimulatory agent, wherein the immunostimulatory agent enhances the subject's immune response to the antigenic composition; and wherein administration of (i) and (ii) is effective for inducing expansion of the antigen-specific CD8 T cells in the subject; and (b) administering to the subject an agonistic anti-TNFR25 antibody which specifically binds TNFR25 in an amount effective enhance the expansion of the antigen-specific CD8 T cells induced in step (a).