Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes

摘要

The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.

主权项

1. A method of treating a subject having suffered a myocardial infarct (MI) comprising delivering to the heart of said subject Tbx5, Gata4, Hand2 and Mef2C expression cassettes.