| 发明名称 |
Conjugated FVIII variants |
| 摘要 |
The present invention relates to conjugated Factor VIII variants. The present invention in particular relates to conjugated FVIII variants comprising different polymeric groups as well as use thereof. |
| 申请公布号 |
US9018166(B2) |
申请公布日期 |
2015.04.28 |
| 申请号 |
US201113577310 |
申请日期 |
2011.02.07 |
| 申请人 |
Novo Nordisk A/S |
发明人 |
Behrens Carsten;Buchardt Jens;Zundel Magali |
| 分类号 |
C07K14/755;A61P7/04;A61K38/37;A61K47/48;A61K38/00 |
主分类号 |
C07K14/755 |
| 代理机构 |
|
代理人 |
Akopyan Nonna G.;Green Reza;Bork Richard W. |
| 主权项 |
1. A Factor VIII (FVIII) variant comprising a FVIII molecule with a truncated B-domain, wherein the truncated B-domain is SEQ ID NO:2, wherein the FVIII variant is covalently heteroconjugated with: (1) at least one poly(ethylene glycol) (PEG) polymer via an O-linked oligosaccharide in the truncated B-domain; and (2) at least one poly(sialic acid) (PSA) polymer via an N-linked oligosaccharide. |
| 地址 |
Bagsvaerd DK |
