Minicell based delivery of biologically active compounds

摘要

Minicells are used to deliver biologically active compounds including radioisotopes, polypeptides, nucleic acids, small molecules, drug molecules, and chemotherapeutic agents. In some cases, the minicell displays ligands or binding moieties that target the minicell to a desired host cell.

主权项

1. A fully intact eubacterial minicell derived from a eubacterial parent cell, wherein the minicell comprises a biologically active compound and displays an antibody or antibody derivative, wherein the biologically active compound is selected from the group consisting of a polypeptide, a small molecule, and a nucleic acid, and wherein the biologically active compound and the antibody or antibody derivative are exogenous to the parent cell and distinct from each other.