发明名称 |
Identification of extracellular form of PTEN that can be used to treat tumors |
摘要 |
An isolated human phosphatase and tensin homolog long polypeptide (PTEN-long) comprising SEQ ID NO:1, fragments and analogs thereof, nucleic acids encoding such and compositions comprising such are provided. Methods to inhibit angiogenesis in a solid tumor, treat a solid tumor, and inhibit growth of a solid tumor using PTEN-long, fragments and analogs thereof, are provided. |
申请公布号 |
US9017981(B2) |
申请公布日期 |
2015.04.28 |
申请号 |
US201013201969 |
申请日期 |
2010.02.17 |
申请人 |
The Trustees of Columbia University in the City of New York |
发明人 |
Parsons Ramon |
分类号 |
C12N9/14;C12N9/16;A61K38/00 |
主分类号 |
C12N9/14 |
代理机构 |
Cooper & Dunham LLP |
代理人 |
White John P.;Cooper & Dunham LLP |
主权项 |
1. A method for treating a solid tumor in a subject comprising administering to the subject an amount of an isolated polypeptide effective to treat the solid tumor in the subject, wherein the sequence of the polypeptide is identical to the sequence set forth in in SEQ ID NO: 1. |
地址 |
New York NY US |