| 发明名称 | Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation | ||
| 摘要 | Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation. | ||
| 申请公布号 | US9018210(B2) | 申请公布日期 | 2015.04.28 |
| 申请号 | US201213730674 | 申请日期 | 2012.12.28 |
| 申请人 | Global Blood Therapeutics, Inc.;Cytokinetics, Inc.;The Regents of the University of California | 发明人 | Metcalf Brian;Chuang Chihyuan |
| 分类号 | C07D487/04;C07D215/14;C07D471/04 | 主分类号 | C07D487/04 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A compound selected from the group consisting of: having the formula: 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde, 2-hydroxy-6-((2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde, and 2-hydroxy-6-((2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde, or pharmaceutically acceptable salt thereof. | ||
| 地址 | South San Francisco CA US | ||