| 主权项 |
1. A compound represented by the formula:or a pharmaceutically acceptable salt thereof, wherein:ring A is
(1) aryl, (2) 9 or 10-membered fused aryl, wherein aryl is fused with a heteroaryl or heterocyclyl group, (3) 6-membered heteroaryl, or (4) 9 or 10-membered fused heteroaryl, wherein the heteroaryl or heterocyclyl groups contain 1-2 N atoms;i or n are independently 0 or 1;m is 1 or 2;k is 0, 1, 2, or 3;each R1 is selected from the group consisting of
(1) halo, (2) C1-6 alkyl, (3) haloC1-6 alkyl (4) hydroxyl, (5) C1-6 alkoxyl, and (6) amino, wherein the alkyl group is unsubstituted or substituted by hydroxy, C1-3alkoxy, or halo;R2a and R2b are independently hydrogen or halo;each R3 is independently hydrogen, halo, C1-6alkyl, or haloC1-6alkyl;R4 is hydrogen, halo, C1-6alkyl, or haloC1-6alkyl; andR5 is selected from the group consisting of
(1) oxo, (2) —COOH, (3) —NH—C(O)C1-6alkyl, (4) —C(O)C1-6alkyl, (5) —C(O)2C1-6alkyl, (6) —C(O)C1-3alkyl-heteroaryl, (7) —C(O)C1-3alkyl-heterocyclyl, (8) —C(O)heterocyclyl, (9) —C(O)C3-6cycloalkyl, (10) —C(O)NH—C1-6alkyl, (11) —C(O)NH—C2-6alkenyl, (12) —C(O)NH—C3-6cycloalkyl, (13) —C(O)NH-heterocyclyl, (14) —C(O)NH—C1-3alkyl-C3-6cycloalkyl, (15) —C(O)NHC1-3alkyl-heterocyclyl, (16) —C(O)NHC1-3alkyl-heteroaryl, (17) —SO2C1-6alkyl, (18) heteroaryl, and (19) CN; wherein the heteroaryl group is a 5- or 6-membered ring, containing 1-4 N, O, or S atoms;wherein the heterocyclyl group is a 3- to 6-membered ring, containing 1-2 N or O atoms; wherein the alkyl group is unsubstituted or substituted by hydroxy, C1-3alkoxy, or halo; and wherein the cycloalkyl, heterocyclyl, or heteroaryl groups are unsubstituted or substituted with 1-3 C1-6alkyl, halo, hydroxy, hydroxyC1-6alkyl, or C1-6alkoxyl groups. |
