| 主权项 |
1. A compound of the formula: or a pharmaceutically acceptable salt thereof,whereinR1 is methyl;R2 is methyl;R3 is hydrogen;L is absent, or is selected from the group consisting of C1-C6 alkylene which may be optionally substituted, C2-C6 alkenylene, C2-C6 alkynylene, —(CH2)p—O—(CH2)n, and —(CH2)p—O—(CH2)z—O—(CH2)n—;n is an integer ranging from 0 to 4;p is an integer ranging from 0 to 4;q is an integer ranging from 0 to 6z is an integer ranging from 1 to 4;D is selected from the group consisting of:
i) (C3-C10)cycloalkyl, optionally substituted, ii) (C6-C10)aryl, optionally substituted, iii) heteroaryl, optionally substituted, iv) heterocyclic, optionally substituted,T is absent, or is —S—(CH2)z—O—(CH2)n, —O—(CH2)z—S—(CH2)n, —(CH2)q—, —(CH2)n—C(O)—(CH2)p—, —(CH2)n—O—(CH2)p—, —(CH2)n—S—(CH2)p, S—C1-C6 alkylene which may be optionally substituted, —O—C1-C6 alkylene which may be optionally substituted, —O—(CH2)p—C(O)—(CH2)n—, —(CH2)p—C(O)—(CH2)q—O—(CH2)n—, —O—(CH2)z—O—(CH2)n—, —O—(CH2)z—O—(CH2)z—O—(CH2)n—, —S—(CH2)z—S—(CH2)n—, —(CH2)n—SH, or —(CH2)n—OH, and;G is absent, or is selected from the group consisting of:
i) (C3-C10)cycloalkyl, optionally substituted; ii) (C6-C10)aryl optionally substituted; iii) heteroaryl, optionally substituted, and; iv) heterocyclic, optionally substituted. |
